Assay Detail
Functional
CHEMBL4135245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 infected in human P4R5 cells assessed as reduction in viral infection preincubated with cells for 24 hrs followed by viral infection measured after 48 hrs by fluorescence based beta-galactosidase reporter gene based MAGI assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 5.20 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.52 |
| CHEMBL4159305 | — | — | 1 | 5.42 |
| CHEMBL4167216 | — | — | 1 | 5.35 |
| CHEMBL4163088 | — | — | 1 | 5.13 |
| CHEMBL4175467 | — | — | 1 | 5.05 |
| CHEMBL183062 | — | — | 1 | 4.96 |
| CHEMBL4176832 | — | — | 1 | 4.85 |
| CHEMBL4170599 | — | — | 1 | 4.80 |
| CHEMBL361350 | — | — | 1 | 4.75 |
| CHEMBL4168270 | — | — | 1 | 4.68 |
| CHEMBL4167025 | — | — | 1 | 4.66 |
| CHEMBL4172336 | — | — | 1 | - |
| CHEMBL4161705 | — | — | 1 | - |
| CHEMBL4162103 | — | — | 1 | - |
| CHEMBL183792 | — | — | 1 | - |
| CHEMBL4170035 | — | — | 1 | - |
| CHEMBL4175393 | — | — | 1 | - |
| CHEMBL4161240 | — | — | 1 | - |
| CHEMBL4176527 | — | — | 1 | - |
| CHEMBL4163126 | — | — | 1 | - |
| CHEMBL4171477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4159305 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4167216 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4163088 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4175467 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL183062 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4176832 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4170599 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL361350 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4168270 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4167025 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4172336 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4161705 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4162103 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL183792 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4170035 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4175393 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4161240 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4176527 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4163126 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4171477 | — | EC50 | > | 20000.0 | nM | - |