Assay Detail
Binding
CHEMBL4135397
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Inhibition of ACE (unknown origin) using Hippuryl-L-Histidyl-L-Leucine as substrate after 60 mins by colorimetric method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic investigations of novel indoxyl-based indolines: A drug target validation and Structure-Activity Relationship of angiotensin-converting enzyme inhibitors with cardiovascular regulation and thrombolytic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.91 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4174467 | — | — | 1 | 8.55 |
| CHEMBL4160421 | — | — | 1 | 8.39 |
| CHEMBL4174072 | — | — | 1 | 8.12 |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | 4.0 | 1 | 8.10 |
| CHEMBL4163792 | — | — | 1 | 8.05 |
| CHEMBL4175518 | — | — | 1 | 8.01 |
| CHEMBL4167651 | — | — | 1 | 7.97 |
| CHEMBL4171024 | — | — | 1 | 7.93 |
| CHEMBL4163798 | — | — | 1 | 7.82 |
| CHEMBL4167252 | — | — | 1 | 7.72 |
| CHEMBL4163389 | — | — | 1 | 7.65 |
| CHEMBL4166152 | — | — | 1 | 7.62 |
| CHEMBL4159339 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4174467 | — | IC50 | = | 2.846 | nM | 8.55 |
| CHEMBL4160421 | — | IC50 | = | 4.11 | nM | 8.39 |
| CHEMBL4174072 | — | IC50 | = | 7.64 | nM | 8.12 |
| CHEMBL1237 | LISINOPRIL ANHYDROUS | IC50 | = | 7.92 | nM | 8.10 |
| CHEMBL4163792 | — | IC50 | = | 8.841 | nM | 8.05 |
| CHEMBL4175518 | — | IC50 | = | 9.82 | nM | 8.01 |
| CHEMBL4167651 | — | IC50 | = | 10.67 | nM | 7.97 |
| CHEMBL4171024 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL4163798 | — | IC50 | = | 15.11 | nM | 7.82 |
| CHEMBL4167252 | — | IC50 | = | 18.97 | nM | 7.72 |
| CHEMBL4163389 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL4166152 | — | IC50 | = | 24.22 | nM | 7.62 |
| CHEMBL4159339 | — | IC50 | = | 112.0 | nM | 6.95 |