Assay Detail
Binding
CHEMBL4135740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hr
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
From PIM1 to PI3Kδ via GSK3β: Target Hopping through the Kinome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.68 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165288 | — | — | 1 | 5.00 |
| CHEMBL4176717 | — | — | 1 | 4.70 |
| CHEMBL4172211 | — | — | 1 | 4.60 |
| CHEMBL4168859 | — | — | 1 | 4.60 |
| CHEMBL4174177 | — | — | 1 | 4.60 |
| CHEMBL4175904 | — | — | 1 | 4.60 |
| CHEMBL260163 | — | — | 1 | - |
| CHEMBL4161596 | — | — | 1 | - |
| CHEMBL4163479 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165288 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4176717 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL4172211 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL4168859 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL4174177 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL4175904 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL260163 | — | IC50 | > | 25118.86 | nM | - |
| CHEMBL4161596 | — | IC50 | > | 25118.86 | nM | - |
| CHEMBL4163479 | — | IC50 | > | 25118.86 | nM | - |