Assay Detail
Binding
CHEMBL4135812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GST-tagged PTP1B catalytic domain expressed in Escherichia coli BL21 using para-nitrophenyl phosphate as substrate
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.98 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161384 | — | — | 1 | 5.87 |
| CHEMBL3632935 | — | — | 1 | 5.59 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 5.48 |
| CHEMBL289191 | LUPEOL | — | 1 | 5.43 |
| CHEMBL4167892 | — | — | 1 | 5.31 |
| CHEMBL4168321 | — | — | 1 | 5.13 |
| CHEMBL4165207 | — | — | 1 | 5.05 |
| CHEMBL4169701 | — | — | 1 | 4.99 |
| CHEMBL4161470 | — | — | 1 | 4.96 |
| CHEMBL4159470 | — | — | 1 | 4.91 |
| CHEMBL4161056 | — | — | 1 | 4.84 |
| CHEMBL518227 | — | — | 1 | 4.78 |
| CHEMBL455357 | — | — | 1 | 4.71 |
| CHEMBL4171661 | — | — | 1 | 4.70 |
| CHEMBL4176168 | — | — | 1 | 4.35 |
| CHEMBL4159975 | — | — | 1 | 4.33 |
| CHEMBL4161770 | — | — | 1 | 4.31 |
| CHEMBL455098 | beta-AMYRIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161384 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL3632935 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL289191 | LUPEOL | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL4167892 | — | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL4168321 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4165207 | — | IC50 | = | 8930.0 | nM | 5.05 |
| CHEMBL4169701 | — | IC50 | = | 10160.0 | nM | 4.99 |
| CHEMBL4161470 | — | IC50 | = | 11080.0 | nM | 4.96 |
| CHEMBL4159470 | — | IC50 | = | 12440.0 | nM | 4.91 |
| CHEMBL4161056 | — | IC50 | = | 14360.0 | nM | 4.84 |
| CHEMBL518227 | — | IC50 | = | 16790.0 | nM | 4.78 |
| CHEMBL455357 | — | IC50 | = | 19260.0 | nM | 4.71 |
| CHEMBL4171661 | — | IC50 | = | 20030.0 | nM | 4.70 |
| CHEMBL4176168 | — | IC50 | = | 44380.0 | nM | 4.35 |
| CHEMBL4159975 | — | IC50 | = | 47350.0 | nM | 4.33 |
| CHEMBL4161770 | — | IC50 | = | 49450.0 | nM | 4.31 |
| CHEMBL455098 | beta-AMYRIN | IC50 | > | 100000.0 | nM | - |