Assay Detail
Binding
CHEMBL4135859
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Inhibition of VEGFR-2 (unknown origin) after 60 mins by ADP-Glo luminescence assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.72 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.07 |
| CHEMBL4175773 | — | — | 1 | 8.68 |
| CHEMBL4171543 | — | — | 1 | 8.63 |
| CHEMBL4171943 | — | — | 1 | 8.10 |
| CHEMBL4166401 | — | — | 1 | 7.67 |
| CHEMBL4174261 | — | — | 1 | 7.54 |
| CHEMBL4163581 | — | — | 1 | 7.46 |
| CHEMBL4165234 | — | — | 1 | 7.39 |
| CHEMBL4170879 | — | — | 1 | 6.97 |
| CHEMBL4162947 | — | — | 1 | 6.90 |
| CHEMBL4169668 | — | — | 1 | 6.49 |
| CHEMBL4175857 | — | — | 1 | - |
| CHEMBL4166703 | — | — | 1 | - |
| CHEMBL4177333 | — | — | 1 | - |
| CHEMBL4174319 | — | — | 1 | - |
| CHEMBL4174711 | — | — | 1 | - |
| CHEMBL4164062 | — | — | 1 | - |
| CHEMBL4159588 | — | — | 1 | - |
| CHEMBL4167913 | — | — | 1 | - |
| CHEMBL4168590 | — | — | 1 | - |
| CHEMBL4161345 | — | — | 1 | - |
| CHEMBL4176454 | — | — | 1 | - |
| CHEMBL4161735 | — | — | 1 | - |
| CHEMBL4173072 | — | — | 1 | - |
| CHEMBL4165168 | — | — | 1 | - |
| CHEMBL4167030 | — | — | 1 | - |
| CHEMBL4163655 | — | — | 1 | - |
| CHEMBL4159125 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL4175773 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4171543 | — | IC50 | = | 2.35 | nM | 8.63 |
| CHEMBL4171943 | — | IC50 | = | 7.97 | nM | 8.10 |
| CHEMBL4166401 | — | IC50 | = | 21.37 | nM | 7.67 |
| CHEMBL4174261 | — | IC50 | = | 28.95 | nM | 7.54 |
| CHEMBL4163581 | — | IC50 | = | 34.68 | nM | 7.46 |
| CHEMBL4165234 | — | IC50 | = | 40.37 | nM | 7.39 |
| CHEMBL4170879 | — | IC50 | = | 108.08 | nM | 6.97 |
| CHEMBL4162947 | — | IC50 | = | 125.32 | nM | 6.90 |
| CHEMBL4169668 | — | IC50 | = | 325.82 | nM | 6.49 |
| CHEMBL4175857 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4166703 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4177333 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4174319 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4174711 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4164062 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4159588 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4167913 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4168590 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4161345 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4176454 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4161735 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4173072 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4165168 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4167030 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4163655 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4159125 | — | IC50 | > | 500.0 | nM | - |