Compound Detail
CHEMBL4161345
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4161345 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RVQNBNHAOAILOW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
376.4
MW (Da)
4.66
ALogP
3
HBA
3
HBD
83.1
PSA (Ų)
0.57
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiopoietin-1 receptor CHEMBL4128 | IC50 | 7.04 | 7.04 | 90.9 | 1 |
| EA.hy 926 CHEMBL4296410 | IC50 | 4.17 | 4.17 | 67420.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiopoietin-1 receptor | IC50 | = | 90.86 | nM | 7.04 | Inhibition of TIE-2 (unknown origin) after 4 hrs by ADP-Glo luminescence assay | 29102175 |
| EA.hy 926 | IC50 | = | 67420.0 | nM | 4.17 | Anti-angiogenic activity in human EAhy926 cells as growth inhibition after 24 hr... | 29102175 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29102175 | 10.1016/j.ejmech.2017.10.030 | Vascular endothelial growth factor receptor 2 | 1 |
| 29102175 | 10.1016/j.ejmech.2017.10.030 | Angiopoietin-1 receptor | 1 |
| 29102175 | 10.1016/j.ejmech.2017.10.030 | EA.hy 926 | 1 |
| 29102175 | 10.1016/j.ejmech.2017.10.030 | Ephrin type-B receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine