Assay Detail
ADMET
CHEMBL4135872
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Anti-angiogenic activity in human EAhy926 cells as growth inhibition after 24 hrs by CCK-8 assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | EA.hy 926 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.54 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4171543 | — | — | 1 | 5.45 |
| CHEMBL4166401 | — | — | 1 | 5.36 |
| CHEMBL4162947 | — | — | 1 | 5.24 |
| CHEMBL4170879 | — | — | 1 | 4.95 |
| CHEMBL4165234 | — | — | 1 | 4.80 |
| CHEMBL4163581 | — | — | 1 | 4.64 |
| CHEMBL4167913 | — | — | 1 | 4.63 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 4.61 |
| CHEMBL4175857 | — | — | 1 | 4.54 |
| CHEMBL4159588 | — | — | 1 | 4.54 |
| CHEMBL4176454 | — | — | 1 | 4.52 |
| CHEMBL4164062 | — | — | 1 | 4.49 |
| CHEMBL4177333 | — | — | 1 | 4.37 |
| CHEMBL4174261 | — | — | 1 | 4.28 |
| CHEMBL4171943 | — | — | 1 | 4.24 |
| CHEMBL4161345 | — | — | 1 | 4.17 |
| CHEMBL4161735 | — | — | 1 | 4.14 |
| CHEMBL4166703 | — | — | 1 | 4.12 |
| CHEMBL4163655 | — | — | 1 | 4.10 |
| CHEMBL4173072 | — | — | 1 | 4.08 |
| CHEMBL4174319 | — | — | 1 | 4.01 |
| CHEMBL4175773 | — | — | 1 | - |
| CHEMBL4168590 | — | — | 1 | - |
| CHEMBL4174711 | — | — | 1 | - |
| CHEMBL4169668 | — | — | 1 | - |
| CHEMBL4159125 | — | — | 1 | - |
| CHEMBL4167030 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4171543 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL4166401 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL4162947 | — | IC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL4170879 | — | IC50 | = | 11220.0 | nM | 4.95 |
| CHEMBL4165234 | — | IC50 | = | 15680.0 | nM | 4.80 |
| CHEMBL4163581 | — | IC50 | = | 22990.0 | nM | 4.64 |
| CHEMBL4167913 | — | IC50 | = | 23330.0 | nM | 4.63 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 24360.0 | nM | 4.61 |
| CHEMBL4175857 | — | IC50 | = | 28990.0 | nM | 4.54 |
| CHEMBL4159588 | — | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL4176454 | — | IC50 | = | 30270.0 | nM | 4.52 |
| CHEMBL4164062 | — | IC50 | = | 32210.0 | nM | 4.49 |
| CHEMBL4177333 | — | IC50 | = | 42440.0 | nM | 4.37 |
| CHEMBL4174261 | — | IC50 | = | 53100.0 | nM | 4.28 |
| CHEMBL4171943 | — | IC50 | = | 57530.0 | nM | 4.24 |
| CHEMBL4161345 | — | IC50 | = | 67420.0 | nM | 4.17 |
| CHEMBL4161735 | — | IC50 | = | 72310.0 | nM | 4.14 |
| CHEMBL4166703 | — | IC50 | = | 76720.0 | nM | 4.12 |
| CHEMBL4163655 | — | IC50 | = | 78780.0 | nM | 4.10 |
| CHEMBL4173072 | — | IC50 | = | 83590.0 | nM | 4.08 |
| CHEMBL4174319 | — | IC50 | = | 96550.0 | nM | 4.01 |
| CHEMBL4175773 | — | IC50 | = | 127230.0 | nM | - |
| CHEMBL4168590 | — | IC50 | = | 113860.0 | nM | - |
| CHEMBL4174711 | — | IC50 | = | 112130.0 | nM | - |
| CHEMBL4169668 | — | IC50 | = | 125960.0 | nM | - |
| CHEMBL4159125 | — | IC50 | = | 141300.0 | nM | - |
| CHEMBL4167030 | — | IC50 | = | 197440.0 | nM | - |