Assay Detail
Binding
CHEMBL4135861
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Inhibition of EphB4 (unknown origin) after 4 hrs by ADP-Glo luminescence assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.41 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4171543 | — | — | 1 | 8.41 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 8.35 |
| CHEMBL4175773 | — | — | 1 | 7.63 |
| CHEMBL4167913 | — | — | 1 | 7.60 |
| CHEMBL4162947 | — | — | 1 | 7.58 |
| CHEMBL4168590 | — | — | 1 | 7.53 |
| CHEMBL4166401 | — | — | 1 | 7.42 |
| CHEMBL4174261 | — | — | 1 | 7.41 |
| CHEMBL4163581 | — | — | 1 | 7.32 |
| CHEMBL4165234 | — | — | 1 | 7.10 |
| CHEMBL4165168 | — | — | 1 | 6.87 |
| CHEMBL4170879 | — | — | 1 | 6.80 |
| CHEMBL4163655 | — | — | 1 | 6.31 |
| CHEMBL4169668 | — | — | 1 | - |
| CHEMBL4171943 | — | — | 1 | - |
| CHEMBL4161345 | — | — | 1 | - |
| CHEMBL4173072 | — | — | 1 | - |
| CHEMBL4176454 | — | — | 1 | - |
| CHEMBL4159125 | — | — | 1 | - |
| CHEMBL4159588 | — | — | 1 | - |
| CHEMBL4161735 | — | — | 1 | - |
| CHEMBL4174711 | — | — | 1 | - |
| CHEMBL4174319 | — | — | 1 | - |
| CHEMBL4167030 | — | — | 1 | - |
| CHEMBL4177333 | — | — | 1 | - |
| CHEMBL4166703 | — | — | 1 | - |
| CHEMBL4175857 | — | — | 1 | - |
| CHEMBL4164062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4171543 | — | IC50 | = | 3.87 | nM | 8.41 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 4.46 | nM | 8.35 |
| CHEMBL4175773 | — | IC50 | = | 23.55 | nM | 7.63 |
| CHEMBL4167913 | — | IC50 | = | 24.92 | nM | 7.60 |
| CHEMBL4162947 | — | IC50 | = | 26.43 | nM | 7.58 |
| CHEMBL4168590 | — | IC50 | = | 29.28 | nM | 7.53 |
| CHEMBL4166401 | — | IC50 | = | 37.78 | nM | 7.42 |
| CHEMBL4174261 | — | IC50 | = | 38.52 | nM | 7.41 |
| CHEMBL4163581 | — | IC50 | = | 47.96 | nM | 7.32 |
| CHEMBL4165234 | — | IC50 | = | 78.92 | nM | 7.10 |
| CHEMBL4165168 | — | IC50 | = | 133.73 | nM | 6.87 |
| CHEMBL4170879 | — | IC50 | = | 160.1 | nM | 6.80 |
| CHEMBL4163655 | — | IC50 | = | 491.93 | nM | 6.31 |
| CHEMBL4169668 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4171943 | — | IC50 | - | — | - | |
| CHEMBL4161345 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4173072 | — | IC50 | - | — | - | |
| CHEMBL4176454 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4159125 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4159588 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4161735 | — | IC50 | - | — | - | |
| CHEMBL4174711 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4174319 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4167030 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4177333 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4166703 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4175857 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4164062 | — | IC50 | > | 500.0 | nM | - |