Assay Detail
Binding
CHEMBL4136260
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Inhibition of recombinant FGFR1 (unknown origin) by off-chip mobility shift assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Indolinone-Based Multikinase Inhibitors as Potential Therapeutics for Idiopathic Pulmonary Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.66 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172546 | — | — | 1 | 7.82 |
| CHEMBL502835 | NINTEDANIB | 4.0 | 1 | 7.39 |
| CHEMBL4165331 | — | — | 1 | 7.36 |
| CHEMBL4177014 | — | — | 1 | 7.21 |
| CHEMBL4160821 | — | — | 1 | 7.21 |
| CHEMBL4162743 | — | — | 1 | 7.03 |
| CHEMBL4170680 | — | — | 1 | 7.00 |
| CHEMBL4171244 | — | — | 1 | 6.92 |
| CHEMBL4166187 | — | — | 1 | 6.85 |
| CHEMBL4166319 | — | — | 1 | 6.85 |
| CHEMBL4175951 | — | — | 1 | 6.77 |
| CHEMBL4169611 | — | — | 1 | 6.70 |
| CHEMBL4161897 | — | — | 1 | 6.57 |
| CHEMBL4172155 | — | — | 1 | 6.21 |
| CHEMBL4168811 | — | — | 1 | 5.80 |
| CHEMBL4165455 | — | — | 1 | 5.75 |
| CHEMBL4161551 | — | — | 1 | 5.33 |
| CHEMBL4173370 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172546 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL502835 | NINTEDANIB | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4165331 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4177014 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4160821 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4162743 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4170680 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4171244 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4166187 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4166319 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4175951 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4169611 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4161897 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4172155 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4168811 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4165455 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4161551 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4173370 | — | IC50 | = | 6600.0 | nM | 5.18 |