Assay Detail
Binding
CHEMBL4136261
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant PDGFRbeta (unknown origin) by off-chip mobility shift assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Indolinone-Based Multikinase Inhibitors as Potential Therapeutics for Idiopathic Pulmonary Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.93 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4177014 | — | — | 1 | 8.82 |
| CHEMBL502835 | NINTEDANIB | 4.0 | 1 | 8.74 |
| CHEMBL4170680 | — | — | 1 | 8.49 |
| CHEMBL4171244 | — | — | 1 | 8.37 |
| CHEMBL4160821 | — | — | 1 | 8.35 |
| CHEMBL4165331 | — | — | 1 | 8.28 |
| CHEMBL4172546 | — | — | 1 | 7.92 |
| CHEMBL4175951 | — | — | 1 | 7.89 |
| CHEMBL4162743 | — | — | 1 | 7.85 |
| CHEMBL4172155 | — | — | 1 | 7.82 |
| CHEMBL4166319 | — | — | 1 | 7.82 |
| CHEMBL4165455 | — | — | 1 | 7.72 |
| CHEMBL4161551 | — | — | 1 | 7.62 |
| CHEMBL4168811 | — | — | 1 | 7.60 |
| CHEMBL4169611 | — | — | 1 | 7.57 |
| CHEMBL4161897 | — | — | 1 | 7.47 |
| CHEMBL4166187 | — | — | 1 | 7.35 |
| CHEMBL4173370 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4177014 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL502835 | NINTEDANIB | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4170680 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4171244 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4160821 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4165331 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4172546 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4175951 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4162743 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4172155 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4166319 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4165455 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4161551 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4168811 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4169611 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4161897 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4166187 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4173370 | — | IC50 | = | 91.0 | nM | 7.04 |