Assay Detail
Binding
CHEMBL4136302
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Agonist activity at human TLR8 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.95 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4162974 | — | — | 1 | 5.66 |
| CHEMBL4162585 | — | — | 1 | 5.42 |
| CHEMBL4170901 | — | — | 1 | 5.27 |
| CHEMBL383322 | RESIQUIMOD | 2.0 | 1 | 5.21 |
| CHEMBL3116322 | — | — | 1 | 5.00 |
| CHEMBL2216760 | — | — | 1 | 4.68 |
| CHEMBL4173277 | — | — | 1 | 4.57 |
| CHEMBL3116325 | — | — | 1 | 4.43 |
| CHEMBL4159198 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4162974 | — | EC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL4162585 | — | EC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL4170901 | — | EC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL383322 | RESIQUIMOD | EC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL3116322 | — | EC50 | = | 9880.0 | nM | 5.00 |
| CHEMBL2216760 | — | EC50 | = | 20860.0 | nM | 4.68 |
| CHEMBL4173277 | — | EC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL3116325 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4159198 | — | EC50 | = | 49800.0 | nM | 4.30 |