Assay Detail
Binding
CHEMBL4136378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-Deltorphin II from mouse FLAG-tagged delta-type opioid receptor expressed in HEK293 cell membranes after 60 mins by gamma counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.65 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165323 | — | — | 1 | 9.00 |
| CHEMBL4166388 | — | — | 1 | 8.83 |
| CHEMBL4173234 | — | — | 1 | 8.68 |
| CHEMBL4164236 | — | — | 1 | 7.22 |
| CHEMBL4161890 | — | — | 1 | 6.82 |
| CHEMBL4169811 | — | — | 1 | 6.78 |
| CHEMBL4174890 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165323 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4166388 | — | IC50 | = | 1.47 | nM | 8.83 |
| CHEMBL4173234 | — | IC50 | = | 2.07 | nM | 8.68 |
| CHEMBL4164236 | — | IC50 | = | 60.7 | nM | 7.22 |
| CHEMBL4161890 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4169811 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL4174890 | — | IC50 | = | 630.0 | nM | 6.20 |