Assay Detail
Functional
CHEMBL4136379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mu-opioid receptor in guinea pig ileum assessed as inhibition of electrically induced contractions
9
Total Activities
9
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.76 | 9.60 |
| IC25 | 1 | - | - |
| IC35 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165323 | — | — | 1 | 9.60 |
| CHEMBL1782140 | — | — | 1 | 9.49 |
| CHEMBL4166388 | — | — | 1 | 9.37 |
| CHEMBL278789 | DERMORPHIN | — | 1 | 8.97 |
| CHEMBL4173234 | — | — | 1 | 8.95 |
| CHEMBL4161890 | — | — | 1 | 7.67 |
| CHEMBL4172559 | — | — | 1 | 7.30 |
| CHEMBL4164236 | — | — | 1 | - |
| CHEMBL4174890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165323 | — | IC50 | = | 0.252 | nM | 9.60 |
| CHEMBL1782140 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL4166388 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL278789 | DERMORPHIN | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL4173234 | — | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL4161890 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL4172559 | — | IC50 | = | 50.4 | nM | 7.30 |
| CHEMBL4164236 | — | IC25 | = | 22.0 | nM | - |
| CHEMBL4174890 | — | IC35 | = | 33.7 | nM | - |