Assay Detail
Functional
CHEMBL4136380
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at delta-type opioid receptor in mouse vas deferens assessed as inhibition of electrically stimulated contractions
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.15 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1782140 | — | — | 1 | 9.38 |
| CHEMBL4173234 | — | — | 1 | 9.07 |
| CHEMBL4166388 | — | — | 1 | 8.96 |
| CHEMBL4165323 | — | — | 1 | 8.85 |
| CHEMBL4164236 | — | — | 1 | 8.07 |
| CHEMBL278789 | DERMORPHIN | — | 1 | 7.75 |
| CHEMBL4172559 | — | — | 1 | 7.33 |
| CHEMBL4174890 | — | — | 1 | 7.04 |
| CHEMBL4161890 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1782140 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL4173234 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL4166388 | — | IC50 | = | 1.09 | nM | 8.96 |
| CHEMBL4165323 | — | IC50 | = | 1.42 | nM | 8.85 |
| CHEMBL4164236 | — | IC50 | = | 8.51 | nM | 8.07 |
| CHEMBL278789 | DERMORPHIN | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL4172559 | — | IC50 | = | 47.1 | nM | 7.33 |
| CHEMBL4174890 | — | IC50 | = | 90.5 | nM | 7.04 |
| CHEMBL4161890 | — | IC50 | = | 114.0 | nM | 6.94 |