Assay Detail
Binding
CHEMBL4136407
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Inhibition of human carbonic anhydrase-1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.19 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163139 | — | — | 1 | 7.01 |
| CHEMBL4177136 | — | — | 1 | 6.63 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL4166184 | — | — | 1 | 6.59 |
| CHEMBL4171057 | — | — | 1 | 6.54 |
| CHEMBL4174497 | — | — | 1 | 6.50 |
| CHEMBL4173293 | — | — | 1 | 6.45 |
| CHEMBL4159776 | — | — | 1 | 6.42 |
| CHEMBL4167691 | — | — | 1 | 6.42 |
| CHEMBL4166065 | — | — | 1 | 6.38 |
| CHEMBL4172094 | — | — | 1 | 6.35 |
| CHEMBL4161495 | — | — | 1 | 6.31 |
| CHEMBL4164241 | — | — | 1 | 6.29 |
| CHEMBL4176682 | — | — | 1 | 6.27 |
| CHEMBL4174896 | — | — | 1 | 6.26 |
| CHEMBL4160012 | — | — | 1 | 6.25 |
| CHEMBL4170654 | — | — | 1 | 6.24 |
| CHEMBL4166821 | — | — | 1 | 6.21 |
| CHEMBL4166580 | — | — | 1 | 6.19 |
| CHEMBL4163368 | — | — | 1 | 6.18 |
| CHEMBL443052 | TAVABOROLE | 4.0 | 1 | 5.70 |
| CHEMBL4174083 | — | — | 1 | 5.46 |
| CHEMBL378506 | BENZOXABOROLE | — | 1 | 5.25 |
| CHEMBL4175131 | — | — | 1 | 5.20 |
| CHEMBL4167266 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163139 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL4177136 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4166184 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL4171057 | — | Ki | = | 288.0 | nM | 6.54 |
| CHEMBL4174497 | — | Ki | = | 318.0 | nM | 6.50 |
| CHEMBL4173293 | — | Ki | = | 355.0 | nM | 6.45 |
| CHEMBL4159776 | — | Ki | = | 385.0 | nM | 6.42 |
| CHEMBL4167691 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL4166065 | — | Ki | = | 417.0 | nM | 6.38 |
| CHEMBL4172094 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL4161495 | — | Ki | = | 487.0 | nM | 6.31 |
| CHEMBL4164241 | — | Ki | = | 514.0 | nM | 6.29 |
| CHEMBL4176682 | — | Ki | = | 532.0 | nM | 6.27 |
| CHEMBL4174896 | — | Ki | = | 548.0 | nM | 6.26 |
| CHEMBL4160012 | — | Ki | = | 557.0 | nM | 6.25 |
| CHEMBL4170654 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL4166821 | — | Ki | = | 613.0 | nM | 6.21 |
| CHEMBL4166580 | — | Ki | = | 639.0 | nM | 6.19 |
| CHEMBL4163368 | — | Ki | = | 654.0 | nM | 6.18 |
| CHEMBL443052 | TAVABOROLE | Ki | = | 2015.0 | nM | 5.70 |
| CHEMBL4174083 | — | Ki | = | 3465.0 | nM | 5.46 |
| CHEMBL378506 | BENZOXABOROLE | Ki | = | 5690.0 | nM | 5.25 |
| CHEMBL4175131 | — | Ki | = | 6352.0 | nM | 5.20 |
| CHEMBL4167266 | — | Ki | = | 9435.0 | nM | 5.03 |