Assay Detail
Functional
CHEMBL4136418
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Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Characteristic α-Acid Derivatives from Humulus lupulus with Antineuroinflammatory Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.68 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253896 | XANTHOHUMOL | 2.0 | 1 | 5.10 |
| CHEMBL4160626 | — | — | 1 | 4.71 |
| CHEMBL4164477 | — | — | 1 | 4.67 |
| CHEMBL4172885 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253896 | XANTHOHUMOL | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL4160626 | — | IC50 | = | 19520.0 | nM | 4.71 |
| CHEMBL4164477 | — | IC50 | = | 21350.0 | nM | 4.67 |
| CHEMBL4172885 | — | IC50 | = | 57690.0 | nM | 4.24 |