Assay Detail
Binding
CHEMBL4136573
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Inhibition of tyrosinase (unknown origin) using L-dihydroxyphenylalanine as substrate preincubated for 30 mins followed by substrate addition measured for 7 mins by spectrophotometric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Artocarmins G-M, Prenylated 4-Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase Inhibitory Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.34 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463145 | NORARTOCARPETIN | — | 1 | 7.64 |
| CHEMBL441343 | PARABEN | — | 1 | 5.03 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.35 |
| CHEMBL4159961 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463145 | NORARTOCARPETIN | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL441343 | PARABEN | IC50 | = | 9350.0 | nM | 5.03 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 44600.0 | nM | 4.35 |
| CHEMBL4159961 | — | IC50 | = | 45300.0 | nM | 4.34 |