Assay Detail
ADMET
CHEMBL4136583
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Cytotoxicity against HEK293 cells after 72 hrs by resazurin dye based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.58 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 6.35 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.31 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 6.16 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 5.54 |
| CHEMBL4163038 | — | — | 1 | 5.30 |
| CHEMBL4173741 | — | — | 1 | 5.27 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 5.16 |
| CHEMBL4165417 | — | — | 1 | 5.15 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469912 | PUROMYCIN | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4163038 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4173741 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4165417 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 9900.0 | nM | 5.00 |