Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4136589

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream forms after 72 hrs by alamar blue staining based fluorescence assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei rhodesiense
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma brucei rhodesiense (CHEMBL612348)
Type ORGANISM
Organism Trypanosoma brucei rhodesiense

Publication

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata.
Kimani NM, Matasyoh JC, Kaiser M, Brun R, Schmidt TJ.
J Nat Prod (2018) 81 : 124 -130
PubMed 29244495 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.99 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL166 MELARSOPROL 3.0 1 8.52
CHEMBL4161256 1 7.00
CHEMBL4176798 1 6.89
CHEMBL4164678 1 6.46
CHEMBL4298697 1 6.41
CHEMBL4169600 1 6.28
CHEMBL4172000 1 6.22
CHEMBL4172980 1 6.09
CHEMBL4160728 1 6.05
CHEMBL4161675 1 6.04
CHEMBL4164230 1 6.04
CHEMBL4168503 1 5.96
CHEMBL490011 1 5.92
CHEMBL4174885 1 5.85
CHEMBL4175311 1 5.77
CHEMBL4165082 1 5.77
CHEMBL4164130 1 5.63
CHEMBL4175998 1 5.58
CHEMBL4177476 1 5.57
CHEMBL4163402 1 5.55
CHEMBL4176361 1 5.40
CHEMBL4165383 1 5.27
CHEMBL78010 PECTOLINARIGENIN 1 5.21
CHEMBL4172439 1 5.14
CHEMBL4175847 1 5.01
CHEMBL4168647 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL166 MELARSOPROL IC50 = 3.0 nM 8.52
CHEMBL4161256 IC50 = 100.0 nM 7.00
CHEMBL4176798 IC50 = 130.0 nM 6.89
CHEMBL4164678 IC50 = 350.0 nM 6.46
CHEMBL4298697 IC50 = 390.0 nM 6.41
CHEMBL4169600 IC50 = 520.0 nM 6.28
CHEMBL4172000 IC50 = 600.0 nM 6.22
CHEMBL4172980 IC50 = 820.0 nM 6.09
CHEMBL4160728 IC50 = 900.0 nM 6.05
CHEMBL4161675 IC50 = 910.0 nM 6.04
CHEMBL4164230 IC50 = 920.0 nM 6.04
CHEMBL4168503 IC50 = 1100.0 nM 5.96
CHEMBL490011 IC50 = 1200.0 nM 5.92
CHEMBL4174885 IC50 = 1400.0 nM 5.85
CHEMBL4175311 IC50 = 1700.0 nM 5.77
CHEMBL4165082 IC50 = 1700.0 nM 5.77
CHEMBL4164130 IC50 = 2340.0 nM 5.63
CHEMBL4175998 IC50 = 2600.0 nM 5.58
CHEMBL4177476 IC50 = 2700.0 nM 5.57
CHEMBL4163402 IC50 = 2800.0 nM 5.55
CHEMBL4176361 IC50 = 4000.0 nM 5.40
CHEMBL4165383 IC50 = 5400.0 nM 5.27
CHEMBL78010 PECTOLINARIGENIN IC50 = 6100.0 nM 5.21
CHEMBL4172439 IC50 = 7300.0 nM 5.14
CHEMBL4175847 IC50 = 9800.0 nM 5.01
CHEMBL4168647 IC50 = 198200.0 nM -