Assay Detail
ADMET
CHEMBL4136608
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Inhibition of recombinant CDK2/cyclin A (unknown origin) using MAHHRSPRKRAKKK as substrate by pyruvate kinase-lactate dehydrogenase coupled assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.21 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170479 | — | — | 1 | 8.15 |
| CHEMBL4174082 | — | — | 1 | 7.96 |
| CHEMBL4162308 | — | — | 1 | 7.77 |
| CHEMBL4166840 | — | — | 1 | 6.85 |
| CHEMBL4165984 | — | — | 1 | 6.83 |
| CHEMBL4167265 | — | — | 1 | 6.77 |
| CHEMBL4173877 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170479 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4174082 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4162308 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4166840 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4165984 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL4167265 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4173877 | — | Ki | = | 750.0 | nM | 6.12 |