Assay Detail
Functional
CHEMBL4136670
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 infected in GFP expressing human MT4 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% normal human serum
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.34 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4177355 | — | — | 1 | 8.55 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.15 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 7.92 |
| CHEMBL4173997 | — | — | 1 | 7.77 |
| CHEMBL4166074 | — | — | 1 | 7.68 |
| CHEMBL3828743 | — | — | 1 | 7.57 |
| CHEMBL4163713 | — | — | 1 | 7.57 |
| CHEMBL4162627 | — | — | 1 | 7.16 |
| CHEMBL4159254 | — | — | 1 | 6.28 |
| CHEMBL4170561 | — | — | 1 | 6.16 |
| CHEMBL4174380 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4177355 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4173997 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4166074 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3828743 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4163713 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4162627 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4159254 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4170561 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4174380 | — | EC50 | = | 1200.0 | nM | 5.92 |