Assay Detail
Binding
CHEMBL4137136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 8.10 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160361 | — | — | 1 | 9.28 |
| CHEMBL519741 | — | — | 1 | 9.08 |
| CHEMBL4160647 | — | — | 1 | 9.00 |
| CHEMBL4162516 | — | — | 1 | 8.97 |
| CHEMBL4163130 | — | — | 1 | 8.96 |
| CHEMBL4174397 | — | — | 1 | 8.81 |
| CHEMBL4174723 | — | — | 1 | 8.78 |
| CHEMBL4169454 | — | — | 1 | 8.76 |
| CHEMBL4167589 | — | — | 1 | 8.74 |
| CHEMBL4160540 | — | — | 1 | 8.73 |
| CHEMBL4161221 | — | — | 1 | 8.67 |
| CHEMBL4175934 | — | — | 1 | 8.65 |
| CHEMBL4172461 | — | — | 1 | 8.57 |
| CHEMBL4175128 | — | — | 1 | 8.56 |
| CHEMBL4165117 | — | — | 1 | 8.55 |
| CHEMBL4163809 | — | — | 1 | 8.54 |
| CHEMBL4167900 | — | — | 1 | 8.52 |
| CHEMBL4175761 | — | — | 1 | 8.45 |
| CHEMBL461754 | — | — | 1 | 8.38 |
| CHEMBL4161062 | — | — | 1 | 8.37 |
| CHEMBL4175333 | — | — | 1 | 8.37 |
| CHEMBL4171253 | — | — | 1 | 8.32 |
| CHEMBL488667 | — | — | 1 | 8.29 |
| CHEMBL4167264 | — | — | 1 | 8.28 |
| CHEMBL461374 | — | — | 1 | 8.15 |
| CHEMBL4167457 | — | — | 1 | 8.14 |
| CHEMBL508870 | — | — | 1 | 8.13 |
| CHEMBL4168968 | — | — | 1 | 7.95 |
| CHEMBL4164402 | — | — | 1 | 7.93 |
| CHEMBL4170226 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160361 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL519741 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL4160647 | — | Ki | = | 1.01 | nM | 9.00 |
| CHEMBL4162516 | — | Ki | = | 1.07 | nM | 8.97 |
| CHEMBL4163130 | — | Ki | = | 1.09 | nM | 8.96 |
| CHEMBL4174397 | — | Ki | = | 1.54 | nM | 8.81 |
| CHEMBL4174723 | — | Ki | = | 1.67 | nM | 8.78 |
| CHEMBL4169454 | — | Ki | = | 1.75 | nM | 8.76 |
| CHEMBL4167589 | — | Ki | = | 1.81 | nM | 8.74 |
| CHEMBL4160540 | — | Ki | = | 1.87 | nM | 8.73 |
| CHEMBL4161221 | — | Ki | = | 2.15 | nM | 8.67 |
| CHEMBL4175934 | — | Ki | = | 2.25 | nM | 8.65 |
| CHEMBL4172461 | — | Ki | = | 2.69 | nM | 8.57 |
| CHEMBL4175128 | — | Ki | = | 2.73 | nM | 8.56 |
| CHEMBL4165117 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL4163809 | — | Ki | = | 2.86 | nM | 8.54 |
| CHEMBL4167900 | — | Ki | = | 3.03 | nM | 8.52 |
| CHEMBL4175761 | — | Ki | = | 3.58 | nM | 8.45 |
| CHEMBL461754 | — | Ki | = | 4.17 | nM | 8.38 |
| CHEMBL4175333 | — | Ki | = | 4.26 | nM | 8.37 |
| CHEMBL4161062 | — | Ki | = | 4.32 | nM | 8.37 |
| CHEMBL4171253 | — | Ki | = | 4.76 | nM | 8.32 |
| CHEMBL488667 | — | Ki | = | 5.07 | nM | 8.29 |
| CHEMBL4167264 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL461374 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4167457 | — | Ki | = | 7.22 | nM | 8.14 |
| CHEMBL508870 | — | Ki | = | 7.48 | nM | 8.13 |
| CHEMBL4168968 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL4164402 | — | Ki | = | 11.67 | nM | 7.93 |
| CHEMBL4170226 | — | Ki | = | 15.7 | nM | 7.80 |
| CHEMBL472521 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL4160009 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL488674 | — | Ki | = | 26.5 | nM | 7.58 |
| CHEMBL452307 | — | Ki | = | 26.8 | nM | 7.57 |
| CHEMBL4175742 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL470094 | — | Ki | = | 89.7 | nM | 7.05 |
| CHEMBL4170651 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL4173300 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL487483 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL4164472 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL4168982 | — | Ki | = | 3490.0 | nM | 5.46 |