Compound Detail
CHEMBL508870
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Basic Information
| ChEMBL ID | CHEMBL508870 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OFLLVGNLDKSIDQ-LDADJPATSA-N |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
411.4
MW (Da)
2.68
ALogP
7
HBA
1
HBD
85.3
PSA (Ų)
0.55
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 8.13
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ras guanyl-releasing protein 3 CHEMBL3638 | Ki | 8.13 | 8.13 | 7.5 | 1 |
| Protein kinase C epsilon type CHEMBL3582 | Ki | 7.74 | 7.74 | 18.2 | 1 |
| Protein kinase C alpha type CHEMBL2567 | Ki | 6.99 | 6.52 | 102.8 | 2 |
| Protein kinase C alpha type CHEMBL299 | Ki | 6.89 | 6.89 | 128.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ras guanyl-releasing protein 3 | Ki | = | 7.48 | nM | 8.13 | Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in ... | 29860841 |
| Protein kinase C epsilon type | Ki | = | 18.2 | nM | 7.74 | Displacement of [3H]PDBu from full length recombinant human PKCepsilon expressed... | 29860841 |
| Protein kinase C alpha type | Ki | = | 102.8 | nM | 6.99 | Displacement of [3H]PDBu form mouse PKCalpha by scintillation counting | 18698758 |
| Protein kinase C alpha type | Ki | = | 128.0 | nM | 6.89 | Displacement of [3H]PDBu from full length recombinant human PKCalpha expressed i... | 29860841 |
| Protein kinase C alpha type | Ki | = | 890.0 | nM | 6.05 | Displacement of [3H]PDBu form mouse PKCalpha by scintillation counting | 18698758 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18698758 | 10.1021/jm8001907 | Protein kinase C alpha type | 3 |
| 29860841 | 10.1021/acs.jmedchem.8b00661 | Unchecked | 2 |
| 29860841 | 10.1021/acs.jmedchem.8b00661 | Protein kinase C alpha type | 1 |
| 29860841 | 10.1021/acs.jmedchem.8b00661 | Protein kinase C epsilon type | 1 |
| 29860841 | 10.1021/acs.jmedchem.8b00661 | Ras guanyl-releasing protein 3 | 1 |
Data from ChEMBL 36 via Core Engine