Assay Detail
Binding
CHEMBL4137134
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PDBu from full length recombinant human PKCalpha expressed in baculovirus expression system after 5 mins by scintillation counting
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 6.99 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160361 | — | — | 1 | 7.87 |
| CHEMBL4167900 | — | — | 1 | 7.81 |
| CHEMBL4172461 | — | — | 1 | 7.60 |
| CHEMBL4160540 | — | — | 1 | 7.59 |
| CHEMBL4167589 | — | — | 1 | 7.59 |
| CHEMBL4175934 | — | — | 1 | 7.56 |
| CHEMBL4175761 | — | — | 1 | 7.54 |
| CHEMBL4174723 | — | — | 1 | 7.54 |
| CHEMBL4175128 | — | — | 1 | 7.52 |
| CHEMBL4174397 | — | — | 1 | 7.52 |
| CHEMBL519741 | — | — | 1 | 7.50 |
| CHEMBL4161221 | — | — | 1 | 7.50 |
| CHEMBL4175333 | — | — | 1 | 7.43 |
| CHEMBL488667 | — | — | 1 | 7.41 |
| CHEMBL4160647 | — | — | 1 | 7.37 |
| CHEMBL4164402 | — | — | 1 | 7.20 |
| CHEMBL4162516 | — | — | 1 | 7.18 |
| CHEMBL4163130 | — | — | 1 | 7.14 |
| CHEMBL4161062 | — | — | 1 | 7.10 |
| CHEMBL461374 | — | — | 1 | 7.08 |
| CHEMBL461754 | — | — | 1 | 7.07 |
| CHEMBL4163809 | — | — | 1 | 6.95 |
| CHEMBL4165117 | — | — | 1 | 6.94 |
| CHEMBL4169454 | — | — | 1 | 6.90 |
| CHEMBL508870 | — | — | 1 | 6.89 |
| CHEMBL4167264 | — | — | 1 | 6.87 |
| CHEMBL4168968 | — | — | 1 | 6.84 |
| CHEMBL4167457 | — | — | 1 | 6.74 |
| CHEMBL472521 | — | — | 1 | 6.73 |
| CHEMBL452307 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160361 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL4167900 | — | Ki | = | 15.6 | nM | 7.81 |
| CHEMBL4172461 | — | Ki | = | 25.2 | nM | 7.60 |
| CHEMBL4160540 | — | Ki | = | 25.65 | nM | 7.59 |
| CHEMBL4167589 | — | Ki | = | 25.4 | nM | 7.59 |
| CHEMBL4175934 | — | Ki | = | 27.6 | nM | 7.56 |
| CHEMBL4175761 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL4174723 | — | Ki | = | 28.77 | nM | 7.54 |
| CHEMBL4175128 | — | Ki | = | 30.4 | nM | 7.52 |
| CHEMBL4174397 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL4161221 | — | Ki | = | 31.3 | nM | 7.50 |
| CHEMBL519741 | — | Ki | = | 31.7 | nM | 7.50 |
| CHEMBL4175333 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL488667 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL4160647 | — | Ki | = | 42.3 | nM | 7.37 |
| CHEMBL4164402 | — | Ki | = | 62.5 | nM | 7.20 |
| CHEMBL4162516 | — | Ki | = | 65.9 | nM | 7.18 |
| CHEMBL4163130 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL4161062 | — | Ki | = | 79.1 | nM | 7.10 |
| CHEMBL461374 | — | Ki | = | 82.2 | nM | 7.08 |
| CHEMBL461754 | — | Ki | = | 84.7 | nM | 7.07 |
| CHEMBL4163809 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL4165117 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL4169454 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL508870 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL4167264 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL4168968 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL4167457 | — | Ki | = | 183.8 | nM | 6.74 |
| CHEMBL472521 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL452307 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL4171253 | — | Ki | = | 249.0 | nM | 6.60 |
| CHEMBL4170226 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL4175742 | — | Ki | = | 383.0 | nM | 6.42 |
| CHEMBL4160009 | — | Ki | = | 439.0 | nM | 6.36 |
| CHEMBL488674 | — | Ki | = | 446.0 | nM | 6.35 |
| CHEMBL470094 | — | Ki | = | 1188.0 | nM | 5.92 |
| CHEMBL487483 | — | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL4170651 | — | Ki | = | 2308.0 | nM | 5.64 |
| CHEMBL4173300 | — | Ki | = | 3640.0 | nM | 5.44 |
| CHEMBL4168982 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL4164472 | — | Ki | > | 30000.0 | nM | - |