Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4138352

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Hep 3B2
Confidence 1 — Organism
Curated By Intermediate

Target

Hep 3B2 (CHEMBL4296437)
Type CELL-LINE
Organism Homo sapiens

Publication

Quinoides and VEGFR2 TKIs influence the fate of hepatocellular carcinoma and its cancer stem cells.
Kahraman DC, Hanquet G, Jeanmart L, Lanners S, Šramel P, Boháč A, Cetin-Atalay R.
Medchemcomm (2017) 8 : 81 -87
PubMed 30108693 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.46 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL194176 1 6.16
CHEMBL4164979 1 6.05
CHEMBL1200485 SORAFENIB TOSYLATE 4.0 1 5.82
CHEMBL3109274 1 5.70
CHEMBL4165836 1 5.68
CHEMBL4164325 1 5.37
CHEMBL255682 1 5.30
CHEMBL4160297 1 5.26
CHEMBL4174446 1 5.00
CHEMBL4170593 1 4.92
CHEMBL4174979 1 4.76
CHEMBL4164116 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL194176 IC50 = 700.0 nM 6.16
CHEMBL4164979 IC50 = 900.0 nM 6.05
CHEMBL1200485 SORAFENIB TOSYLATE IC50 = 1500.0 nM 5.82
CHEMBL3109274 IC50 = 2000.0 nM 5.70
CHEMBL4165836 IC50 = 2100.0 nM 5.68
CHEMBL4164325 IC50 = 4300.0 nM 5.37
CHEMBL255682 IC50 = 5000.0 nM 5.30
CHEMBL4160297 IC50 = 5500.0 nM 5.26
CHEMBL4174446 IC50 = 9900.0 nM 5.00
CHEMBL4170593 IC50 = 12000.0 nM 4.92
CHEMBL4174979 IC50 = 17400.0 nM 4.76
CHEMBL4164116 IC50 - -