Assay Detail
Binding
CHEMBL4138413
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]BNtxA from mouse MOR expressed in CHO cell membranes after 90 mins by filter binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.32 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165157 | — | — | 1 | 8.90 |
| CHEMBL4159603 | — | — | 1 | 8.70 |
| CHEMBL4168572 | — | — | 1 | 8.48 |
| CHEMBL4173059 | — | — | 1 | 8.43 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.34 |
| CHEMBL4167519 | — | — | 1 | 8.16 |
| CHEMBL4167929 | — | — | 1 | 8.15 |
| CHEMBL4176436 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165157 | — | Ki | = | 1.25 | nM | 8.90 |
| CHEMBL4159603 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4168572 | — | Ki | = | 3.29 | nM | 8.48 |
| CHEMBL4173059 | — | Ki | = | 3.73 | nM | 8.43 |
| CHEMBL70 | MORPHINE | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL4167519 | — | Ki | = | 6.91 | nM | 8.16 |
| CHEMBL4167929 | — | Ki | = | 7.02 | nM | 8.15 |
| CHEMBL4176436 | — | Ki | = | 40.59 | nM | 7.39 |