Assay Detail
Binding
CHEMBL4138414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]BNtxA from mouse KOR expressed in CHO cell membranes after 90 mins by filter binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.25 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165157 | — | — | 1 | 7.72 |
| CHEMBL4159603 | — | — | 1 | 7.11 |
| CHEMBL4168572 | — | — | 1 | 6.92 |
| CHEMBL4167929 | — | — | 1 | - |
| CHEMBL4167519 | — | — | 1 | - |
| CHEMBL4173059 | — | — | 1 | - |
| CHEMBL4176436 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165157 | — | Ki | = | 18.97 | nM | 7.72 |
| CHEMBL4159603 | — | Ki | = | 77.9 | nM | 7.11 |
| CHEMBL4168572 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL4167929 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4167519 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4173059 | — | Ki | > | 100.0 | nM | - |
| CHEMBL4176436 | — | Ki | > | 100.0 | nM | - |