Assay Detail
Binding
CHEMBL4138430
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Displacement of [3H]GR113808 from serotonin 5-HT4 receptor in Dunkin-Hartley guinea pigs striatal nuclei membranes incubated for 2 hrs by liquid scintillation counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multivalent ligands for the serotonin 5-HT<sub>4</sub> receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.90 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79637 | — | — | 1 | 8.41 |
| CHEMBL4162531 | — | — | 1 | 8.40 |
| CHEMBL4172346 | — | — | 1 | 8.40 |
| CHEMBL4172315 | — | — | 1 | 8.35 |
| CHEMBL286136 | — | — | 1 | 8.22 |
| CHEMBL4164469 | — | — | 1 | 8.05 |
| CHEMBL4170461 | — | — | 1 | 7.89 |
| CHEMBL83954 | — | — | 1 | 7.72 |
| CHEMBL74656 | REL-CISAPRIDE | — | 1 | 7.70 |
| CHEMBL4165966 | — | — | 1 | 7.52 |
| CHEMBL4167048 | — | — | 1 | 7.21 |
| CHEMBL4159138 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79637 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL4162531 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4172346 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4172315 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL286136 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4164469 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL4170461 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL83954 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL74656 | REL-CISAPRIDE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL4165966 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4167048 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL4159138 | — | Ki | = | 121.0 | nM | 6.92 |