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Assay Detail

CHEMBL4138525

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Binding
Inhibition of Human parainfluenza virus type 3 hemagglutinin-neuraminidase using MUN as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins by fluorescence assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human respirovirus 3
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Hemagglutinin-neuraminidase (CHEMBL1764934)
Type SINGLE PROTEIN
Organism Human parainfluenza virus 1

Publication

Exploring inhibitor structural features required to engage the 216-loop of human parainfluenza virus type-3 hemagglutinin-neuraminidase.
El-Deeb IM, Guillon P, Dirr L, von Itzstein M.
Medchemcomm (2017) 8 : 130 -134
PubMed 30108698 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.56 5.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4173228 1 5.84
CHEMBL213310 1 5.23
CHEMBL4169804 1 4.41
CHEMBL4171759 1 4.35
CHEMBL4174507 1 4.31
CHEMBL4161883 1 4.19
CHEMBL4166382 1 4.15
CHEMBL4162923 1 4.00
CHEMBL4174607 1 -
CHEMBL4177327 1 -
CHEMBL4166695 1 -
CHEMBL4171975 1 -
CHEMBL4161380 1 -
CHEMBL4175418 1 -
CHEMBL4164792 1 -
CHEMBL4160313 1 -
CHEMBL4168227 1 -
CHEMBL4163680 1 -
CHEMBL4171569 1 -
CHEMBL4163956 1 -
CHEMBL4159969 1 -
CHEMBL4173639 1 -
CHEMBL4165393 1 -
CHEMBL4167887 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4173228 IC50 = 1430.0 nM 5.84
CHEMBL213310 IC50 = 5910.0 nM 5.23
CHEMBL4169804 IC50 = 38900.0 nM 4.41
CHEMBL4171759 IC50 = 45100.0 nM 4.35
CHEMBL4174507 IC50 = 48700.0 nM 4.31
CHEMBL4161883 IC50 = 64800.0 nM 4.19
CHEMBL4166382 IC50 = 71000.0 nM 4.15
CHEMBL4162923 IC50 = 99600.0 nM 4.00
CHEMBL4174607 IC50 > 150000.0 nM -
CHEMBL4177327 IC50 > 150000.0 nM -
CHEMBL4166695 IC50 > 150000.0 nM -
CHEMBL4171975 IC50 > 150000.0 nM -
CHEMBL4161380 IC50 > 150000.0 nM -
CHEMBL4175418 IC50 > 150000.0 nM -
CHEMBL4164792 IC50 > 150000.0 nM -
CHEMBL4160313 IC50 > 150000.0 nM -
CHEMBL4168227 IC50 > 150000.0 nM -
CHEMBL4163680 IC50 > 150000.0 nM -
CHEMBL4171569 IC50 > 150000.0 nM -
CHEMBL4163956 IC50 > 150000.0 nM -
CHEMBL4159969 IC50 > 150000.0 nM -
CHEMBL4173639 IC50 > 150000.0 nM -
CHEMBL4165393 IC50 = 103500.0 nM -
CHEMBL4167887 IC50 > 150000.0 nM -