Assay Detail
Binding
CHEMBL4138641
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PRMT1 (unknown origin) assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H4-20-Biotin at 10 uM pre-incubated for 3 mins before [3H]-SAM addition and measured after 15 mins by scintillation proximity assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 1 (CHEMBL5524) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.44 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3245413 | — | — | 1 | 4.89 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 4.66 |
| CHEMBL25105 | HEXAMIDINE | 2.0 | 1 | 4.28 |
| CHEMBL142304 | STILBAMIDINE | 2.0 | 1 | 4.28 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3245413 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL25105 | HEXAMIDINE | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL142304 | STILBAMIDINE | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 81000.0 | nM | 4.09 |