Assay Detail
Binding
CHEMBL4139280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to full length C-terminal FLAG tagged human SMS2 S217A mutant expressed in HEK293 cells after 120 mins by AS/MS analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Phosphatidylcholine:ceramide cholinephosphotransferase 2 (CHEMBL3112379) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 6.62 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4172856 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4172856 | — | Kd | = | 240.0 | nM | 6.62 |