Assay Detail
Binding
CHEMBL4139734
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Antagonist activity at Adenosine receptor in human RBC assessed as change in erythrocyte morphology incubated for 3 hrs with occasional gentle stirring for every 30 min measured for every 12 hrs by microscopic analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RBC |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
Nanomolar anti-sickling compounds identified by ligand-based pharmacophore approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.68 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168653 | — | — | 1 | 5.29 |
| CHEMBL4163380 | — | — | 1 | 5.06 |
| CHEMBL4167064 | — | — | 1 | 4.21 |
| CHEMBL273807 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168653 | — | EC50 | = | 5128.61 | nM | 5.29 |
| CHEMBL4163380 | — | EC50 | = | 8709.64 | nM | 5.06 |
| CHEMBL4167064 | — | EC50 | = | 61659.5 | nM | 4.21 |
| CHEMBL273807 | — | EC50 | = | 67608.3 | nM | 4.17 |