Adenosine receptor · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-13Adenosine receptor shows approved-linked disease relevance led by Airway obstruction. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P30542. Start with Airway obstruction, then reuse UniProt P30542 as the stable protein anchor across project notes and exports.
Start with Airway obstruction, then reuse UniProt P30542 as the stable protein anchor across project notes and exports.
Adenosine receptor shows approved-linked disease relevance led by Airway obstruction. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.
Start review with Airway obstruction because it currently carries approved-linked support. Linked drugs include AMINOPHYLLINE, OXTRIPHYLLINE, THEOPHYLLINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAdenosine receptor A1
Review this target as Adenosine receptor, mapped to UniProt P30542. ChEMBL maps the protein component as Adenosine receptor A1. Sequence length is 326 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Adenosine receptor as ChEMBL target CHEMBL2111329, mapped to UniProt P30542. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Adenosine receptor is the right protein anchor across sources, using UniProt P30542 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Airway obstruction is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Adenosine receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P30542 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Adenosine receptor A1 |
| UniProt Accession | P30542 |
| Component Type | Protein |
| Sequence Length | 326 aa |
Adenosine receptor A1
Review this target as Adenosine receptor, mapped to UniProt P30542. ChEMBL maps the protein component as Adenosine receptor A1. Sequence length is 326 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Adenosine receptor shows approved-linked disease relevance led by Airway obstruction. 5 more disease programs remain visible in the same review block.
Start review with Airway obstruction because it currently carries approved-linked support. Linked drugs include AMINOPHYLLINE, OXTRIPHYLLINE, THEOPHYLLINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4168653 | 5.29 | EC50 | 5128.61 | Preclinical |
| CHEMBL4163380 | 5.06 | EC50 | 8709.64 | Preclinical |
| CHEMBL2112109 | 4.37 | Ki | 42500.0 | Preclinical |
| CHEMBL4167064 | 4.21 | EC50 | 61659.5 | Preclinical |
| CHEMBL273807 | 4.17 | EC50 | 67608.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 6 | 1 | 4.4 |
| cell-based format | 1 | 4 | 4.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |