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Compound Detail

CHEMBL2112109

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Nc1ncnc2c1ncn2[C@H]1CN[C@@H](CO)C1

Basic Information

ChEMBL ID CHEMBL2112109
Phase Preclinical
Structure Type MOL
InChI Key LIMGOFPYHUEMJW-RNFRBKRXSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

234.3
MW (Da)
-0.70
ALogP
7
HBA
3
HBD
101.9
PSA (Ų)
0.64
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H14N6O
MW 234.26
Aromatic Rings 2
Heavy Atoms 17
NP-Likeness 0.68

Activity Summary

Ki 1 meas. best 4.37

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor
CHEMBL2111329
Ki 4.37 4.37 42500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Adenosine receptor Ki = 42500.0 nM 4.37 Binding affinity towards adenosine receptor 1654429

Literature References

PubMed DOI Target Context # Activities
1654429 10.1021/jm00113a017 Adenosine receptor 1

Data from ChEMBL 36 via Core Engine