Assay Detail
Functional
CHEMBL4139738
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of novel indole derivatives as promising DNA-binding agents and evaluation of antitumor and antitopoisomerase I activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.31 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.57 |
| CHEMBL4161864 | — | — | 1 | 5.44 |
| CHEMBL541474 | — | — | 1 | 4.91 |
| CHEMBL4167215 | — | — | 1 | - |
| CHEMBL4175081 | — | — | 1 | - |
| CHEMBL1917018 | — | — | 1 | - |
| CHEMBL1910509 | — | — | 1 | - |
| CHEMBL4175862 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL4161864 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL541474 | — | IC50 | = | 12430.0 | nM | 4.91 |
| CHEMBL4167215 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4175081 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1917018 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1910509 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4175862 | — | IC50 | > | 50000.0 | nM | - |