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Assay Detail

CHEMBL4139760

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat brain FAAH using [3H]AEA as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fatty-acid amide hydrolase 1 (CHEMBL3229)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Novel propanamides as fatty acid amide hydrolase inhibitors.
Deplano A, Morgillo CM, Demurtas M, Björklund E, Cipriano M, Svensson M, Hashemian S, Smaldone G, Pedone E, Luque FJ, Cabiddu MG, Novellino E, Fowler CJ, Catalanotti B, Onnis V.
Eur J Med Chem (2017) 136 : 523 -542
PubMed 28535469 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.21 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL191534 1 5.92
CHEMBL1316 CARPROFEN 4.0 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL191534 IC50 = 1200.0 nM 5.92
CHEMBL1316 CARPROFEN IC50 = 32000.0 nM 4.50