Assay Detail
Functional
CHEMBL4139824
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Cytotoxicity against human H69 cells assessed as decrease in cell viability after 48 hrs by resazurin dye-based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H69 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pentapeptides for the treatment of small cell lung cancer: Optimisation by Nind-alkyl modification of the tryptophan side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.59 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4167069 | — | — | 1 | 9.20 |
| CHEMBL4175749 | — | — | 1 | 9.00 |
| CHEMBL4165141 | — | — | 1 | 8.80 |
| CHEMBL4161710 | — | — | 1 | 8.74 |
| CHEMBL4160638 | — | — | 1 | 8.74 |
| CHEMBL4164039 | — | — | 1 | 8.55 |
| CHEMBL4168560 | — | — | 1 | 8.40 |
| CHEMBL4172341 | — | — | 1 | 8.39 |
| CHEMBL4171911 | — | — | 1 | 7.51 |
| CHEMBL4159158 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4167069 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL4175749 | — | IC50 | = | 1.01 | nM | 9.00 |
| CHEMBL4165141 | — | IC50 | = | 1.57 | nM | 8.80 |
| CHEMBL4161710 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4160638 | — | IC50 | = | 1.83 | nM | 8.74 |
| CHEMBL4164039 | — | IC50 | = | 2.84 | nM | 8.55 |
| CHEMBL4168560 | — | IC50 | = | 3.98 | nM | 8.40 |
| CHEMBL4172341 | — | IC50 | = | 4.05 | nM | 8.39 |
| CHEMBL4171911 | — | IC50 | = | 30.74 | nM | 7.51 |
| CHEMBL4159158 | — | IC50 | > | 30.0 | nM | - |