Assay Detail
Functional
CHEMBL4139825
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Cytotoxicity against human DMS79 cells assessed as decrease in cell viability after 48 hrs by resazurin dye-based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DMS-79 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pentapeptides for the treatment of small cell lung cancer: Optimisation by Nind-alkyl modification of the tryptophan side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.48 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4175749 | — | — | 1 | 8.85 |
| CHEMBL4160638 | — | — | 1 | 8.72 |
| CHEMBL4165141 | — | — | 1 | 8.72 |
| CHEMBL4167069 | — | — | 1 | 8.64 |
| CHEMBL4161710 | — | — | 1 | 8.62 |
| CHEMBL4172341 | — | — | 1 | 8.41 |
| CHEMBL4168560 | — | — | 1 | 8.39 |
| CHEMBL4164039 | — | — | 1 | 8.36 |
| CHEMBL4171911 | — | — | 1 | 7.64 |
| CHEMBL4159158 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4175749 | — | IC50 | = | 1.43 | nM | 8.85 |
| CHEMBL4160638 | — | IC50 | = | 1.92 | nM | 8.72 |
| CHEMBL4165141 | — | IC50 | = | 1.91 | nM | 8.72 |
| CHEMBL4167069 | — | IC50 | = | 2.31 | nM | 8.64 |
| CHEMBL4161710 | — | IC50 | = | 2.37 | nM | 8.62 |
| CHEMBL4172341 | — | IC50 | = | 3.88 | nM | 8.41 |
| CHEMBL4168560 | — | IC50 | = | 4.03 | nM | 8.39 |
| CHEMBL4164039 | — | IC50 | = | 4.37 | nM | 8.36 |
| CHEMBL4171911 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4159158 | — | IC50 | > | 30.0 | nM | - |