Assay Detail
Functional
CHEMBL4140752
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Antiproliferative activity against human CCRF-CEM cells after 96 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Triazolopyridinyl-acrylonitrile derivatives as antimicrotubule agents: Synthesis, in vitro and in silico characterization of antiproliferative activity, inhibition of tubulin polymerization and binding thermodynamics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.25 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.68 |
| CHEMBL4174684 | — | — | 1 | 6.12 |
| CHEMBL4163335 | — | — | 1 | 6.00 |
| CHEMBL4174066 | — | — | 1 | 5.92 |
| CHEMBL4171645 | — | — | 1 | 5.75 |
| CHEMBL4166148 | — | — | 1 | 5.60 |
| CHEMBL4171238 | — | — | 1 | 5.13 |
| CHEMBL4170633 | — | — | 1 | 5.11 |
| CHEMBL4161042 | — | — | 1 | 5.07 |
| CHEMBL4177429 | — | — | 1 | 5.00 |
| CHEMBL4167882 | — | — | 1 | 4.95 |
| CHEMBL4159962 | — | — | 1 | 4.81 |
| CHEMBL4162707 | — | — | 1 | 4.79 |
| CHEMBL4169577 | — | — | 1 | 4.66 |
| CHEMBL4167247 | — | — | 1 | 4.52 |
| CHEMBL4175091 | — | — | 1 | 4.49 |
| CHEMBL4164453 | — | — | 1 | 4.47 |
| CHEMBL4159334 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4174684 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4163335 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4174066 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4171645 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4166148 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4171238 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4170633 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4161042 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4177429 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4167882 | — | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4159962 | — | EC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL4162707 | — | EC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL4169577 | — | EC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL4167247 | — | EC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL4175091 | — | EC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL4164453 | — | EC50 | = | 33700.0 | nM | 4.47 |
| CHEMBL4159334 | — | EC50 | = | 43600.0 | nM | 4.36 |