Assay Detail
Binding
CHEMBL4140789
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Inhibition of tubulin polymerization (unknown origin) preincubated for 10 mins followed by GTP addition measured after 20 mins by Coomassie blue staining based SDS-PAGE analysis
22
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
Triazolopyridinyl-acrylonitrile derivatives as antimicrotubule agents: Synthesis, in vitro and in silico characterization of antiproliferative activity, inhibition of tubulin polymerization and binding thermodynamics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.61 | 6.82 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376464 | — | — | 1 | 6.82 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.58 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.09 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.88 |
| CHEMBL4174684 | — | — | 2 | 4.76 |
| CHEMBL4163335 | — | — | 1 | 4.62 |
| CHEMBL4174066 | — | — | 1 | 4.54 |
| CHEMBL4171238 | — | — | 1 | - |
| CHEMBL4159962 | — | — | 1 | - |
| CHEMBL4167882 | — | — | 1 | - |
| CHEMBL4175091 | — | — | 1 | - |
| CHEMBL4162707 | — | — | 1 | - |
| CHEMBL4170633 | — | — | 1 | - |
| CHEMBL4159334 | — | — | 1 | - |
| CHEMBL4167247 | — | — | 1 | - |
| CHEMBL4169577 | — | — | 1 | - |
| CHEMBL4177429 | — | — | 1 | - |
| CHEMBL4166148 | — | — | 1 | - |
| CHEMBL4161042 | — | — | 1 | - |
| CHEMBL4171645 | — | — | 1 | - |
| CHEMBL4164453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376464 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL61 | PODOFILOX | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4174684 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL4163335 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL4174066 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL4175091 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4164453 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4171645 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4161042 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4166148 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4177429 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4167882 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4167247 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4159334 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4170633 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4162707 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4159962 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4171238 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4174684 | — | Inhibition | - | % | - | |
| CHEMBL4169577 | — | IC50 | > | 30000.0 | nM | - |