Assay Detail
Functional
CHEMBL4141932
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Cytotoxicity against human UACC-903 cells assessed as cell viability at 25 uM after 48 hrs by MTT assay relative to control
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UACC-903 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.06 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160982 | — | — | 1 | 5.64 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 5.44 |
| CHEMBL4167822 | — | — | 1 | 5.42 |
| CHEMBL4170805 | — | — | 1 | 5.40 |
| CHEMBL4164820 | — | — | 1 | 5.38 |
| CHEMBL4160028 | — | — | 1 | 5.34 |
| CHEMBL4159910 | — | — | 1 | 5.26 |
| CHEMBL4173688 | — | — | 1 | 5.21 |
| CHEMBL4168259 | — | — | 1 | 5.19 |
| CHEMBL4175037 | — | — | 1 | 5.17 |
| CHEMBL4177462 | — | — | 1 | 5.12 |
| CHEMBL4171596 | — | — | 1 | 5.11 |
| CHEMBL4165444 | — | — | 1 | 5.10 |
| CHEMBL4167289 | — | — | 1 | 5.10 |
| CHEMBL402646 | — | — | 1 | 5.04 |
| CHEMBL4164388 | — | — | 1 | 4.87 |
| CHEMBL4163392 | — | — | 1 | 4.84 |
| CHEMBL4174100 | — | — | 1 | 4.82 |
| CHEMBL493922 | — | — | 1 | 4.79 |
| CHEMBL4163124 | — | — | 1 | 4.75 |
| CHEMBL4173840 | — | — | 1 | 4.74 |
| CHEMBL4176101 | — | — | 1 | 4.74 |
| CHEMBL1383244 | — | — | 1 | 4.73 |
| CHEMBL4165771 | — | — | 1 | 4.68 |
| CHEMBL4175148 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160982 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4167822 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4170805 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4164820 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4160028 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4159910 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4173688 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4168259 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4175037 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4177462 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4171596 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4165444 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4167289 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL402646 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4164388 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4163392 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL4174100 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL493922 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL4163124 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4173840 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4176101 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL1383244 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL4165771 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4175148 | — | IC50 | = | 23400.0 | nM | 4.63 |