Assay Detail
Functional
CHEMBL4142292
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Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.36 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218105 | BOROPINIC ACID | — | 1 | 6.16 |
| CHEMBL4175759 | — | — | 1 | 5.66 |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | 5.54 |
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | — | 1 | 5.15 |
| CHEMBL2268532 | 7-(2-PENTYNYLOXY)COUMARIN | — | 1 | 4.30 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218105 | BOROPINIC ACID | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4175759 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL51628 | UMBELLIFERONE | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2268532 | 7-(2-PENTYNYLOXY)COUMARIN | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL45 | MELATONIN | IC50 | = | 18000000.0 | nM | - |