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Assay Detail

CHEMBL4142294

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Functional
Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Intermediate

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration.
Hasan M, Genovese S, Fiorito S, Epifano F, Witt-Enderby PA.
J Nat Prod (2017) 80 : 3324 -3329
PubMed 29144746 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.54 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL145781 7-BENZYLOXYCOUMARIN 1 9.40
CHEMBL32749 FERULATE -1.0 1 6.30
CHEMBL45 MELATONIN 4.0 1 6.05
CHEMBL51628 UMBELLIFERONE 1 5.43
CHEMBL4175759 1 5.18
CHEMBL221960 1 4.66
CHEMBL156127 UMBELLIPRENIN 1 4.52
CHEMBL2022666 BOROPINAL 1 4.20
CHEMBL307341 AURAPTENE 1 4.10
CHEMBL218105 BOROPINIC ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL145781 7-BENZYLOXYCOUMARIN IC50 = 0.4 nM 9.40
CHEMBL32749 FERULATE IC50 = 500.0 nM 6.30
CHEMBL45 MELATONIN IC50 = 900.0 nM 6.05
CHEMBL51628 UMBELLIFERONE IC50 = 3700.0 nM 5.43
CHEMBL4175759 IC50 = 6600.0 nM 5.18
CHEMBL221960 IC50 = 22000.0 nM 4.66
CHEMBL156127 UMBELLIPRENIN IC50 = 30000.0 nM 4.52
CHEMBL2022666 BOROPINAL IC50 = 63000.0 nM 4.20
CHEMBL307341 AURAPTENE IC50 = 80000.0 nM 4.10
CHEMBL218105 BOROPINIC ACID IC50 = 0.0008 nM -