Assay Detail
Functional
CHEMBL4143754
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Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of novel quinacrine-[1,3]-thiazinan-4-one hybrids for their anti-breast cancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.31 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4166078 | — | — | 1 | 6.16 |
| CHEMBL4175854 | — | — | 1 | 6.00 |
| CHEMBL4160733 | — | — | 1 | 5.78 |
| CHEMBL4173568 | — | — | 1 | 5.73 |
| CHEMBL4165232 | — | — | 1 | 5.73 |
| CHEMBL4161112 | — | — | 1 | 5.64 |
| CHEMBL4172446 | — | — | 1 | 5.51 |
| CHEMBL4176222 | — | — | 1 | 5.47 |
| CHEMBL4175818 | — | — | 1 | 5.47 |
| CHEMBL4176699 | — | — | 1 | 5.45 |
| CHEMBL4165607 | — | — | 1 | 5.42 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 5.38 |
| CHEMBL4176931 | — | — | 1 | 5.37 |
| CHEMBL4165637 | — | — | 1 | 5.36 |
| CHEMBL4169449 | — | — | 1 | 5.32 |
| CHEMBL4165003 | — | — | 1 | 5.30 |
| CHEMBL4169039 | — | — | 1 | 5.30 |
| CHEMBL4177301 | — | — | 1 | 5.26 |
| CHEMBL4168654 | — | — | 1 | 5.15 |
| CHEMBL4169502 | — | — | 1 | 5.05 |
| CHEMBL4167959 | — | — | 1 | 4.81 |
| CHEMBL4161586 | — | — | 1 | 4.79 |
| CHEMBL4161803 | — | — | 1 | 4.50 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 4.42 |
| CHEMBL4169067 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4166078 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4175854 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4160733 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4173568 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4165232 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4161112 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL4172446 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL4176222 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL4175818 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4176699 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL4165607 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL4176931 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL4165637 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL4169449 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL4165003 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL4169039 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL4177301 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL4168654 | — | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL4169502 | — | IC50 | = | 8940.0 | nM | 5.05 |
| CHEMBL4167959 | — | IC50 | = | 15350.0 | nM | 4.81 |
| CHEMBL4161586 | — | IC50 | = | 16180.0 | nM | 4.79 |
| CHEMBL4161803 | — | IC50 | = | 31310.0 | nM | 4.50 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 38440.0 | nM | 4.42 |
| CHEMBL4169067 | — | IC50 | = | 39330.0 | nM | 4.41 |