Assay Detail
Binding
CHEMBL4143891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular calcium level incubated for 5 mins followed by agonist stimulation by Fluo4-AM probe based fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily M member 8 (CHEMBL5011) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.49 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74415 | CANNABINOL | 3.0 | 1 | 6.68 |
| CHEMBL4170268 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74415 | CANNABINOL | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4170268 | — | IC50 | = | 500.0 | nM | 6.30 |