Assay Detail
Binding
CHEMBL4144022
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Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 0.5 hrs by scintillation counting method
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 8.36 | 8.63 |
| Bmax | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4175820 | — | — | 2 | 8.63 |
| CHEMBL4168626 | — | — | 2 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4175820 | — | Kd | = | 2.34 | nM | 8.63 |
| CHEMBL4168626 | — | Kd | = | 8.12 | nM | 8.09 |
| CHEMBL4175820 | — | Bmax | = | 974.0 | cpm | - |
| CHEMBL4168626 | — | Bmax | = | 3417.0 | cpm | - |