Assay Detail
Functional
CHEMBL4144408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MOLM13 cells after 72 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.96 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 8.33 |
| CHEMBL371358 | GOIAZENSOLIDE | — | 1 | 6.07 |
| CHEMBL4159192 | — | — | 1 | 5.96 |
| CHEMBL4168591 | — | — | 1 | 5.37 |
| CHEMBL4298697 | — | — | 1 | 5.00 |
| CHEMBL4160672 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL371358 | GOIAZENSOLIDE | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4159192 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4168591 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4298697 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4160672 | — | IC50 | = | 10000.0 | nM | 5.00 |