Assay Detail
Binding
CHEMBL4144750
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ACE (unknown origin) using hippuryl-L-histidyl-L-leucine as substrate preincubated with substrate for 30 mins followed by enzyme addition measured after 30 mins by LC/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Metabolomics-Guided Discovery of Microginin Peptides from Cultures of the Cyanobacterium Microcystis aeruginosa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.65 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.60 |
| CHEMBL858 | EDETIC ACID | 3.0 | 1 | 4.85 |
| CHEMBL4161811 | — | — | 1 | 4.51 |
| CHEMBL4172457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL858 | EDETIC ACID | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4161811 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4172457 | — | IC50 | = | 460000.0 | nM | - |