Assay Detail
Binding
CHEMBL4144828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of IK-698 from Escherichia coli LeuRS by isothermal titration calorimetric calorimetry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Leucine--tRNA ligase (CHEMBL4295566) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain K12) |
Publication
N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.74 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163450 | — | — | 1 | 8.00 |
| CHEMBL4171058 | — | — | 1 | 7.99 |
| CHEMBL4163140 | — | — | 1 | 7.96 |
| CHEMBL4172643 | — | — | 1 | 7.89 |
| CHEMBL4159778 | — | — | 1 | 7.86 |
| CHEMBL4161986 | — | — | 1 | 7.84 |
| CHEMBL4167692 | — | — | 1 | 7.66 |
| CHEMBL4174152 | — | — | 1 | 7.25 |
| CHEMBL4171458 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163450 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4171058 | — | Kd | = | 10.2 | nM | 7.99 |
| CHEMBL4163140 | — | Kd | = | 10.9 | nM | 7.96 |
| CHEMBL4172643 | — | Kd | = | 12.8 | nM | 7.89 |
| CHEMBL4159778 | — | Kd | = | 13.9 | nM | 7.86 |
| CHEMBL4161986 | — | Kd | = | 14.5 | nM | 7.84 |
| CHEMBL4167692 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL4174152 | — | Kd | = | 56.0 | nM | 7.25 |
| CHEMBL4171458 | — | Kd | = | 64.0 | nM | 7.19 |