Assay Detail
Binding
CHEMBL4144830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli LeuRS expressed in Escherichia coli M15 cells assessed as reduction in ATP consumption
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Leucine--tRNA ligase (CHEMBL4295566) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain K12) |
Publication
N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.42 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4163140 | — | — | 1 | 7.89 |
| CHEMBL4172643 | — | — | 1 | 7.85 |
| CHEMBL4159778 | — | — | 1 | 7.64 |
| CHEMBL4171058 | — | — | 1 | 7.50 |
| CHEMBL4160841 | — | — | 1 | 7.46 |
| CHEMBL4163450 | — | — | 1 | 7.39 |
| CHEMBL4167692 | — | — | 1 | 7.33 |
| CHEMBL4161986 | — | — | 1 | 7.27 |
| CHEMBL4171458 | — | — | 1 | 7.19 |
| CHEMBL4174152 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4163140 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4172643 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4159778 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4171058 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4160841 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4163450 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4167692 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4161986 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4171458 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4174152 | — | IC50 | = | 224.0 | nM | 6.65 |